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| FIXTURE DATE | HOME TEAM | SCORE | AWAY TEAM | LOCATION |
| 2021-05-18 | Woolston A | | | Penketh | Woolston |
| 2021-05-25 | Penketh | | | Tetleys A | Penketh |
| 2021-06-01 | Penketh | | | Orford WM A | Penketh |
| 2021-06-08 | Monks B | | | Penketh | Monks |
| 2021-06-15 | Penketh | | | Vulcan B | Penketh |
| 2021-06-22 | Vulcan A | | | Penketh | Vulcan |
| 2021-06-29 | Penketh | | | Padgate A | Penketh |
| 2021-07-06 | St Oswalds A | | | Penketh | St Oswalds |
| 2021-07-13 | Penketh | | | Woolston B | Penketh |
| 2021-07-20 | Penketh | | | Woolston A | Penketh |
| 2021-07-27 | Tetleys A | | | Penketh | Tetleys |
| 2021-08-03 | Orford WM A | | | Penketh | OWM |
| 2021-08-10 | Penketh | | | Monks B | Penketh |
| 2021-08-17 | Vulcan B | | | Penketh | Vulcan |
| 2021-08-24 | Penketh | | | Vulcan A | Penketh |
| 2021-08-31 | Padgate A | | | Penketh | Padgate |
| 2021-09-07 | Penketh | | | St Oswalds A | Penketh |
| 2021-09-14 | Woolston B | | | Penketh | Woolston |